Suggested Level of Knowlege: Detailed

LOs

IT_GS 1.1 Outline the basic pharmacology of sedative/hypnotic agents (propofol, thiopentone, midazolam, ketamine), inhalational agents, opioids, muscle relaxants, reversal drugs and anti- emetic agents relevant to their clinical practice.

BT_GS 1.46 Discuss factors influencing choice of agents for:

· Sedation

· Induction and maintenance of anaesthesia

· Muscle relaxation

BT_GS 1.57 Explain the techniques of intravenous and inhalational induction and describe clinical indications and advantages and disadvantages of both techniques

Past SAQs

2017.1 Propofol and remifentanil target controlled infusions are often given together as a total intravenous anaesthesia technique. Discuss pharmacological reasons why this is a useful combination.

2012.2 Compare and contrast propofol and sevoflurane for maintenance of anaesthesia with respect to kinetics, cardiovascular and central nervous system effects.

2012.1 Discuss the suitability of ketamine as an intravenous anaesthetic agent.

2007.1 Discuss the suitability of ketamine as a total intravenous anaesthetic agent in comparison with propofol.

IV Agent Clinical Usage