Suggested Level of Knowlege: Detailed

LOs

BT_GS 1.30 Describe and compare the pharmacokinetics of intravenous induction and sedative agents, the factors which affect recovery from intravenous anaesthesia and the clinical implications of these differences

Past SAQs

2015.1, 2010.1 Describe the time course between an intravenous injection of a general anaesthetic agent to loss of consciousness. Explain the delay using pharmacokinetic principles.

2005.2, 2001.1  Define the term ‘context-sensitive half time’. How does it differ from the half life typically quoted for a drug? Illustrate this concept by comparing thiopentone vs. propofol and fentanyl vs. remifentanil.

2004.2 Outline the factors which influence the elimination half-life of propofol.

IV Agent Pharmacokinetics