Suggested Level of Knowlege: Detailed

LOs

BT_RA 1.3 Discuss the pharmacology of local anaesthetic agents including:

· Mechanisms of action

· Comparative pharmacology of different agents

· Toxicity

· Use of adjuvant agents to enhance the quality or extend duration of block

· Pharmacokinetics of drugs administered in the epidural and subarachnoid space

Past SAQs

2010.1 Describe how the chemical structure of local anaesthetic drugs determines their efficacy and safety.

2003.1 Explain how lignocaine prevents the conduction of a nerve action potential.

LA: Mechanisms of Action and Structure Activity Relationships