Suggested Level of Knowlege: Detailed

LOs

BT_RA 1.3 Discuss the pharmacology of local anaesthetic agents including:

· Mechanisms of action

· Comparative pharmacology of different agents

· Toxicity

· Use of adjuvant agents to enhance the quality or extend duration of block

· Pharmacokinetics of drugs administered in the epidural and subarachnoid space

Past SAQs

2017.1 Discuss the factors affecting duration of action of a local anaesthetic block to a major peripheral nerve.

2016.1 Discuss the factors influencing the speed of onset of blockade, of a major peripheral nerve, with local anaesthetic. 


2007.1 After epidural injection in a health term pregnant woman, discuss the factors influencing the distribution of bupivacaine to (a) the maternal CSF

and spinal cord; (b) the maternal circulation; (c) the foetus.

2006.1, 2003.2 Write short notes on factors affecting the speed of onset and duration of effect of local anaesthetics when used to produce peripheral nerve block.

2000.2 Write short notes on factors affecting the speed of onset and duration of local anaesthetics when used to produce peripheral nerve block.

LA Pharmacokinetics