Suggested Level of Knowlege: Detailed

LOs

IT_PM 1.4 Outline the basic pharmacology and clinical use of available analgesic agents.

BT_PM 1.24 Classify non-steroidal anti-inflammatory drugs and outline their pharmacology in relation to enzyme inhibition, mode of administration and adverse effects.

BT_PM 1.25 Describe in detail pharmacology of paracetamol including mode of action, clinical utility, metabolism and toxicity, advantages and disadvantages of different routes of administration

BT_PO 1.89 Outline the role of prostaglandins and other autocoids

SS_OB 1.11 Describe the pharmacology of tocolytic agents with particular reference to beta 2 agonists, calcium antagonists, magnesium, inhalational anaesthetics, nitrates and NSAIDS

Past SAQs

2014.1 Compare and contrast the management of an overdose of aspirin with that of an overdose of paracetamol.

2013.2, 2010.1 Describe how non steroidal anti-inflammatory drugs exert their clinical effects. Outline the advantages and disadvantages in using COX-2 selective agents.

2012.1 List the side effects of non-steroidal anti-inflammatory drugs. Briefly explain the mechanisms responsible for each of these side effects

2011.2 Describe the pathogenesis and management of paracetamol toxicity.

2006.2 Briefly explain the mechanisms responsible for non-steroidal anti- inflammatory drug (NSAID) – induced side effects. Outline the advantages and disadvantages of selective cyclooxygenase (COX 2)

inhibitors.

2006.2 Describe the pathogenesis and management of paracetamol toxicity.

2003.2, 2000.1 Describe the pharmacological effects of paracetamol. Outline its toxicity and management.

2002.1 Outline the mechanism of action of non-steroidal anti-inflammatory drugs and their potential adverse effects.

References

NSAIDS