Suggested Level of Knowlege: Detailed

LOs

IT_GS 1.1 Outline the basic pharmacology of sedative/hypnotic agents (propofol, thiopentone, midazolam, ketamine), inhalational agents, opioids, muscle relaxants, reversal drugs and anti- emetic agents relevant to their clinical practice.

IT_PM 1.4 Outline the basic pharmacology and clinical use of available analgesic agents.

BT_PM 1.9 Describe the pharmacology of the following agents applicable to pain management, including:

· Opioids

· Tramadol

· Local anaesthetic agents (also refer to the Regional and local anaesthesia clinical fundamental)

· NSAIDs

· Paracetamol

· NMDA antagonists

· Anticonvulsants

· Antidepressants

· Corticosteroids ·

Inhalational analgesics - nitrous oxide, methoxyflurane

BT_PM 1.21 Describe the pharmacology of opioid antagonists

Past SAQs

2012.1, 2005.2, 1999.2 Using opioids as examples describe and illustrate with graphs what you understand by the terms "potency", "efficacy", "partial agonist", "competitive antagonist", and "therapeutic index".

2011.1 Describe the ideal properties of agents used for sedation using two examples.

2011.1,1999.1 Write a brief outline on the pharmacology of remifentanil.

2006.1 Briefly outline the pharmacology of naloxone.

2004.2 Write short notes on tramadol.

2002.2 Write brief notes on tolerance and dependence in relation to opioid analgesics.

Opioids General & Comparative