Suggested Level of Knowlege: Detailed

LOs

BT_GS 1.3 Define and explain dose-effect relationships of drugs with reference to:

· Graded and quantal response

· Therapeutic index

· Potency and efficacy

· Competitive and non-competitive antagonists

· Partial agonists, mixed agonist-antagonists and inverse agonists

· Additive and synergistic effects of drug combinations

BT_GS 1.4 Describe efficacy and potency with reference to dose- response curves

BT_PM 1.14 Describe the actions of agonists, partial agonists, mixed agonists-antagonists and antagonists

Past SAQs

2014.1, 2013.2 Draw and explain the characteristics of a log dose-response curve that describes the major clinical effect of rocuronium. Describe how factors encountered in clinical practice may alter this curve

2012.1, 2005.2, 1999.2 Using opioids as examples describe and illustrate with graphs what you understand by the terms "potency", "efficacy", "partial agonist", "competitive antagonist", and "therapeutic index".

Dose Response Curves