Suggested Level of Knowlege: Detailed

LOs

BT_GS 1.1 Explain the concept of drug action with respect to:

· Receptor theory

· Enzyme interactions

· Physico-chemical interactions

BT_GS 1.2 Explain receptor activity with regard to:

· Ionic fluxes

· Second messengers and G proteins

· Nucleic acid synthesis

· Evidence for the presence of receptors

· Regulation of receptor number and activity

BT_GS 1.5 Explain the law of mass action and describe affinity and dissociation constants

Past SAQs

2004.2, 2001.1 Briefly describe how drugs produce their pharmacological effects. Illustrate each mechanism with examples.