Suggested Level of Knowlege: Detailed

LOs

BT_GS 1.10 Describe the mechanisms of drug clearance and how physiological and pathological disturbance may affect these

BT_GS 1.11 Describe the mechanisms of non-hepatic and hepatic metabolism of drugs including:

· Phase one and phase two reactions

· Hepatic extraction ratio and its significance

· First pass effect, enzyme induction and inhibition

Past SAQs

2000.1 Discuss the roles of plasma esterases on drugs used in anaesthesia.

Drug Metabolism & Clearance