Suggested Level of Knowlege: Detailed

LOs

BT_GS 1.17 Describe alterations to drug response due to pathological disturbance with particular reference to cardiac, respiratory, renal and hepatic disease

BT_GS 1.33 Describe how physiological and pathological disturbance can alter the pharmacology of intravenous anaesthetic agents

BT_PM 1.10 Describe the effect of physiological change and pathological disturbance on the pharmacology of the agents listed in learning outcome BT PM 1.9 (Opioids, Tramadol, Local anaesthetic agents,  NSAIDs,  Paracetamol,  NMDA antagonists,  Anticonvulsants,  Antidepressants,  Corticosteroids,  Inhalational analgesics - nitrous oxide,methoxyflurane), with special reference to the elderly

BT_PO 1.80 Describe alterations to drug response due to renal disease

BT_PO 1.108 Describe alterations to drug response due to hepatic disease

Past SAQs

2015.2 Describe how morbid obesity affects time to awakening after inhalation anaesthesia.

2011.1 Outline the effects of liver failure on drug kinetics and dynamics.

2009.2 Describe the effect of obesity on pharmacokinetics and the potential clinical implications, providing relevant examples.

2004.1 Outline the effects of liver failure on drug kinetics and dynamics.

Physiological & Pathological Variations