Suggested Level of Knowlege: Detailed

LOs

BT_PO 1.43 Discuss the physiological basis of electrical activity and its relationship to mechanical events including the:

· Ionic basis of automaticity the normal and abnormal processes of cardiac excitation

· Physiological basis of the electrocardiograph in normal and common pathological states

· Factors that may influence cardiac electrical activity

· Correlation of the mechanical events of the cardiac cycle with the electrical and ionic events

BT_PO 1.56 Describe the physiological and pharmacological basis of antiarrhythmic therapy including classification based on electro-physiological activity and mechanism of action

Past SAQs

2016.2 Compare and contrast the action potentials from the sino-atrial node and a ventricular myocyte.

2011.2 Describe the ionic basis of automaticity of cardiac pacemaker cells.

2007.2 Draw and label a lead II electrocardiogram (ECG) tracing for one cardiac cycle, indicating normal values. What is the PR interval and what

factors influence it?

2002.1 Draw a labelled diagram of a cardiac muscle action potential highlighting the sequence of changes in ionic conductances. Explain the terms “threshold”, “excitability”, and “irritability” with the aid of the

diagram.

References

Electrical Activity